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PublicacionsThe hidden health effects of endocrine-disrupting chemicals.
Nat Rev Endocrinol. 2026 Feb;22(2):70-71.
doi: 10.1038/s41574-025-01222-9. PMID: 41381822
Increased TGF-β/Activin-Smad2 signaling is associated with pancreatic β-cell dysfunction and glucose intolerance in gestational diabetes mellitus.
Mol Metab. 2025 Oct 18;103:102274.
doi: 10.1016/j.molmet.2025.102274. PMID: 41115652
Inhibition of glucagon secretion from pancreatic α-cells by the bile acid TUDCA involves a S1PR2-PI3K pathway.
J Nutr Biochem. 2025 Aug 19;146:110076.
doi: 10.1016/j.jnutbio.2025.110076. PMID: 40840642.
Hyperglucagonemia and glucagon hypersecretion in early type 2 diabetes result from multifaceted dysregulation of pancreatic mouse α-cells.
Pflugers Arch. 2025 Feb;477(2):207-221.
doi: 10.1007/s00424-024-03045-5. Epub 2024 Nov 27. PMID: 39601887
SUCNR1 regulates insulin secretion and glucose elevates the succinate response in people with prediabetes.
J Clin Invest. 2024 May 7;134(12):e173214.
doi: 10.1172/JCI173214.PMID: 38713514
Endocrine disruptors in plastics alter β-cell physiology and increase the risk of diabetes mellitus.
Am J Physiol Endocrinol Metab. 2023 Jun 1;324(6):E488-E505.
doi: 10.1152/ajpendo.00068.2023. Epub 2023 May 3. PMID: 37134142
Exploring the Effects of Metabolism-Disrupting Chemicals on Pancreatic α-Cell Viability, Gene Expression and Function: A Screening Testing Approach.
Int J Mol Sci. 2023 Jan 5;24(2):1044.
doi: 10.3390/ijms24021044.PMID: 36674557
Acute and chronic effects of the organophosphate malathion on the pancreatic α and β cell viability, cell structure, and voltage-gated K+ currents.
Environ Toxicol Pharmacol. 2023 Mar;98:104046.
doi: 10.1016/j.etap.2022.104046. Epub 2022 Dec 29.PMID: 36587778
Preconception exposure to malathion and glucose homeostasis in rats: Effects on dams during pregnancy and post-term periods, and on their progeny.
Environ Pollut. 2023 Jan 1;316(Pt 2):120633.
doi: 10.1016/j.envpol.2022.120633. Epub 2022 Nov 9.PMID: 36370973
ReadEDTest: A tool to assess the readiness of in vitro test methods under development for identifying endocrine disruptors.
Environ Int. 2023 Apr;174:107910.
doi: 10.1016/j.envint.2023.107910. Epub 2023 Mar 31.PMID: 37028267
The second-generation antipsychotic drug aripiprazole modulates the serotonergic system in pancreatic islets and induces beta cell dysfunction in female mice.
Grajales D, Vázquez P, Ruíz-Rosario M, Tudurí E, Mirasierra M, Ferreira V, Hitos AB, Koller D, Zubiaur P, Cigudosa JC, Abad-Santos F, Vallejo M, Quesada I, Tirosh B, Leibowitz G, Valverde ÁM.
Diabetologia. 2022 Mar;65(3):490-505.
doi: 10.1007/s00125-021-05630-0
Insulin-degrading enzyme ablation in mouse pancreatic alpha cells triggers cell proliferation, hyperplasia and glucagon secretion dysregulation.
Merino B, Casanueva-Álvarez E, Quesada I, González-Casimiro CM, Fernández-Díaz CM, Postigo-Casado T, Leissring MA, Kaestner KH, Perdomo G, Cózar-Castellano I.
Diabetologia. 2022 Aug;65(8):1375-1389.
doi: 10.1007/s00125-022-05729-y
The pancreatic β-cell in ageing: Implications in age-related diabetes.
Tudurí E, Soriano S, Almagro L, Montanya E, Alonso-Magdalena P, Nadal Á, Quesada I.
Ageing Res Rev. 2022 Sep;80:101674.
doi: 10.1016/j.arr.2022.101674
Bisphenol-S and Bisphenol-F alter mouse pancreatic β-cell ion channel expression and activity and insulin release through an estrogen receptor ERβ mediated pathway.
Marroqui L, Martinez-Pinna J, Castellano-Muñoz M, Dos Santos RS, Medina-Gali RM, Soriano S, Quesada I, Gustafsson JA, Encinar JA, Nadal A.
Chemosphere. 2021 Feb;265:129051
doi: 10.1016/j.chemosphere.2020.129051
Bisphenol-A exposure during pregnancy alters pancreatic β-cell division and mass in male mice offspring: A role for ERβ.
Boronat-Belda T, Ferrero H, Al-Abdulla R, Quesada I, Gustafsson JA, Nadal Á, Alonso-Magdalena P.
Food Chem Toxicol. 2020 Nov;145:111681.
doi: 10.1016/j.fct.2020.111681
The Commonly Overlooked Factor. Commentary on: "Environmental Obesogens and their Impact on Susceptibility to Obesity".
Alonso-Magdalena P, Nadal A.
Endocrinology. 2020 Sep 1;161(9):bqaa123
doi: 10.1210/endocr/bqaa123
Postprandial Lipemia Modulates Pancreatic Alpha-Cell Function in the Prediction of Type 2 Diabetes Development: The CORDIOPREV Study.
Pozuelo-Sanchez I, Villasanta-Gonzalez A, Alcala-Diaz JF, Vals-Delgado C, Leon-Acuña A, Gonzalez-Requero A, Yubero-Serrano EM, Luque RM, Caballero-Villarraso J, Quesada I, Ordovas JM, Pérez-Martinez P, Roncero-Ramos I, Lopez-Miranda J.
J Agric Food Chem. 2020 Feb 5;68(5):1266-1275.
doi: 10.1021/acs.jafc.9b06801
Morphological and functional adaptations of pancreatic alpha-cells during late pregnancy in the mouse.
Quesada-Candela C, Tudurí E, Marroquí L, Alonso-Magdalena P, Quesada I, Nadal Á.
Metabolism. 2020 Jan;102:153963.
doi: 10.1016/j.metabol.2019.153963
- Integrative Strategy of Testing Systems for Identification of Endocrine Disruptors Inducing Metabolic Disorders-An Introduction to the OBERON Project.
Audouze K, Sarigiannis D, Alonso-Magdalena P, Brochot C, Casas M, Vrijheid M, Babin PJ, Karakitsios S, Coumoul X, Barouki R.
Int J Mol Sci. 2020 Apr 23;21(8):2988.
doi: 10.3390/ijms21082988
In utero exposure to bisphenol-A disrupts key elements of retinoid system in male mice offspring.
Esteban J, Serrano-Maciá M, Sánchez-Pérez I, Alonso-Magdalena P, Pellín MC, García-Arévalo M, Nadal Á, Barril J.
Food Chem Toxicol. 2019 Apr;126:142-151.
doi: 10.1016/j.fct.2019.02.023
Pancreatic alpha-cell mass in the early-onset and advanced stage of a mouse model of experimental autoimmune diabetes.
Bru-Tari E, Cobo-Vuilleumier N, Alonso-Magdalena P, Dos Santos RS, Marroqui L, Nadal A, Gauthier BR, Quesada I.
Sci Rep. 2019 Jul 2;9(1):9515.
doi: 10.1038/s41598-019-45853-1
Bisphenol A Regulates Sodium Ramp Currents in Mouse Dorsal Root Ganglion Neurons and Increases Nociception.
Soriano S, Gil-Rivera M, Marroqui L, Alonso-Magdalena P, Fuentes E, Gustafsson JA, Nadal A, Martinez-Pinna J.
Sci Rep. 2019 Jul 16;9(1):10306.
doi: 10.1038/s41598-019-46769-6
Oestrogen receptor β mediates the actions of bisphenol-A on ion channel expression in mouse pancreatic beta cells.
Martinez-Pinna J, Marroqui L, Hmadcha A, Lopez-Beas J, Soriano S, Villar-Pazos S, Alonso-Magdalena P, Dos Santos RS, Quesada I, Martin F, Soria B, Gustafsson JÅ, Nadal A.
Diabetologia. 2019 Sep;62(9):1667-1680.
doi: 10.1007/s00125-019-4925-y
Cortistatin regulates glucose-induced electrical activity and insulin secretion in mouse pancreatic beta-cells.
Soriano S, Castellano-Muñoz M, Rafacho A, Alonso-Magdalena P, Marroquí L, Ruiz-Pino A, Bru-Tarí E, Merino B, Irles E, Bello-Pérez M, Iborra P, Villar-Pazos S, Vettorazzi JF, Montanya E, Luque RM, Nadal Á, Quesada I.
Mol Cell Endocrinol. 2019 Jan 5;479:123-132.
doi: 10.1016/j.mce.2018.09.009
Environmental Pollutants in Pancreatic Beta-Cells and the Onset of Diabetes Mellitus.
Alonso-Magdalena P, Tuduri E, Marroqui L, Quesada I, Sargis RM, Nadal A.
Encyclopedia of Endocrine Diseases.
765-775, 2019 Editorial: Elsevier Inc. Oxford
Effects of bisphenol A treatment during pregnancy on kidney development in mice: a stereological and histopathological study.
Nuñez P, Fernandez T, García-Arévalo M, Alonso-Magdalena P, Nadal A, Perillan C, Arguelles J.
J Dev Orig Health Dis. 2018 Apr;9(2):208-214.
doi: 10.1017/S2040174417000939
Mitochondria as target of endocrine-disrupting chemicals: implications for type 2 diabetes.
Marroqui L, Tudurí E, Alonso-Magdalena P, Quesada I, Nadal Á, Dos Santos RS.
J Endocrinol. 2018 Nov 1;239(2):R27-R45.
doi: 10.1530/JOE-18-0362
- Timing of Exposure and Bisphenol-A: Implications for Diabetes Development.
Tudurí E, Marroqui L, Dos Santos RS, Quesada I, Fuentes E, Alonso-Magdalena P.
Front Endocrinol (Lausanne). 2018 Oct 31;9:648.
doi: 10.3389/fendo.2018.00648
GATA6 Controls Insulin Biosynthesis and Secretion in Adult β-Cells.
Villamayor L, Rodríguez-Seguel E, Araujo R, Carrasco M, Bru-Tarí E, Mellado-Gil JM, Gauthier BR, Martinelli P, Quesada I, Soria B, Martín F, Cano DA, Rojas A. Diabetes.
2018 Mar;67(3):448-460.
doi: 10.2337/db17-0364
- A Calcium-Dependent Chloride Current Increases Repetitive Firing in Mouse Sympathetic Neurons.
Martinez-Pinna J, Soriano S, Tudurí E, Nadal A, de Castro F.
Front Physiol. 2018 May 14;9:508.
doi: 10.3389/fphys.2018.00508