{"id":849,"date":"2022-11-28T14:13:00","date_gmt":"2022-11-28T13:13:00","guid":{"rendered":"https:\/\/dialab.umh.es\/?page_id=849"},"modified":"2023-06-30T10:38:08","modified_gmt":"2023-06-30T08:38:08","slug":"proyecto-prometeo","status":"publish","type":"page","link":"https:\/\/dialab.umh.es\/es\/proyecto-prometeo\/","title":{"rendered":"Proyecto Prometeo"},"content":{"rendered":"

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DIABESITY AND ISLET REARCH LAB<\/span><\/p>\n

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Proyecto Prometeo<\/span><\/strong><\/h1>\n

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OBJETIVOS<\/span><\/strong><\/span><\/h2>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\u00bb1_5,3_5,1_5″ _builder_version=\u00bb4.17.4″ _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb1_5″ _builder_version=\u00bb4.17.4″ _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_text _builder_version=\u00bb4.17.4″ _module_preset=\u00bbdefault\u00bb text_text_color=\u00bb#ab1a2d\u00bb text_font_size=\u00bb100px\u00bb header_font=\u00bb|700|||||||\u00bb header_font_size=\u00bb100px\u00bb header_line_height=\u00bb1.2em\u00bb header_2_text_color=\u00bb#ab1a2d\u00bb header_2_font_size=\u00bb100px\u00bb header_2_line_height=\u00bb1.2em\u00bb custom_margin=\u00bb|||32px|false|false\u00bb border_width_right=\u00bb3px\u00bb border_color_right=\u00bb#333399″ global_colors_info=\u00bb{}\u00bb]<\/p>\n

1<\/strong><\/span><\/h2>\n

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Estudiar el papel de la activaci\u00f3n de los receptores de estr\u00f3genos en ER\u03b2 y GPER\u00a0en la viabilidad de la c\u00e9lula-\u03b2 en presencia y ausencia de est\u00edmulos apopt\u00f3ticos.<\/strong><\/p>\n

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2<\/strong><\/span><\/h2>\n

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Analizar el efecto de la disminuci\u00f3n de la expresi\u00f3n de los receptores de estr\u00f3genos ER\u03b2 y GPER<\/strong>, usando RNA de interferencia, en la viabilidad celular.<\/p>\n

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3<\/strong><\/span><\/h2>\n

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Caracterizaci\u00f3n del papel de ER\u03b2 y GPER en la secreci\u00f3n de glucag\u00f3n,<\/strong>\u00a0y en la viabilidad celular de la c\u00e9lula-\u03b1.<\/span><\/p>\n

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Regulaci\u00f3n de la viabilidad y la funci\u00f3n de las c\u00e9lulas \u03b2 y \u03b1 pancre\u00e1ticas por los receptores de estr\u00f3genos ER\u03b2 y GPER: papel en la terapia de la diabetes mellitus<\/strong><\/p>\n

El 17\u03b2-estradiol (E2) es una hormona sexual producida por la c\u00e9lula de las granulosas en el ovario, que est\u00e1 tradicionalmente implicada en la diferenciaci\u00f3n sexual, la pubertad y la reproducci\u00f3n. En las dos \u00faltimas d\u00e9cadas el impacto del E2 ha trascendido a muchas otras funciones fisiol\u00f3gicas, entre ellas, la homeostasis de la glucosa, incluyendo sus efectos en las c\u00e9lulas \u03b2 y \u03b1 del p\u00e1ncreas endocrino. El E2regula el contenido de insulina y su secreci\u00f3n en respuesta a la glucosa, y produce elefecto contrario en el caso de la c\u00e9lula-\u03b1 y la secreci\u00f3n de glucag\u00f3n. Tambi\u00e9n protege a la c\u00e9lula-\u03b2 de la muerte celular en respuesta a est\u00edmulos apopt\u00f3ticos y no se sabe si hace lo mismo en la c\u00e9lula-\u03b1. El papel del receptor de estr\u00f3genos ER\u03b1 en la funci\u00f3n y la supervivencia de la c\u00e9lula-\u03b2 est\u00e1 relativamente bien estudiado. No ocurre igual con los otros dos receptores de estr\u00f3genos, ER\u03b2 y GPER. La disecci\u00f3n de los mecanismos de acci\u00f3n del E2 a trav\u00e9s de los receptores de estr\u00f3genos ER\u03b2 y GPER en el p\u00e1ncreas endocrino que proponemos en este proyecto, nos ayudaran a conocer mejor las diferencias de sexo en la homeostasis de la glucosa. Este conocimiento ayudar\u00e1 a mejorar el tratamiento de la diabetes mellitus tipo 2, los efectos secundarios de la hormonoterapia para determinados tipos de canceres hormonodependientes y a comprender la fisiolog\u00eda transg\u00e9nero.<\/p>\n

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PUBLICACIONES<\/span><\/strong><\/span><\/h2>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\u00bb1_3,1_3,1_3″ use_custom_gutter=\u00bbon\u00bb gutter_width=\u00bb2″ make_equal=\u00bbon\u00bb _builder_version=\u00bb4.16″ max_width=\u00bb100%\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb1_3″ _builder_version=\u00bb4.16″ background_color=\u00bbrgba(255,255,255,0.39)\u00bb custom_padding=\u00bb30px|30px|30px|30px\u00bb box_shadow_style=\u00bbpreset1″ global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_blurb title=\u00bbMart\u00ednez-Pinna J, Sempere-Navarro R, Medina-Gali RM, Fuentes E, Quesada I, Sargis RM, Trasande L, Nadal A. (2023)\u00bb url_new_window=\u00bbon\u00bb content_max_width=\u00bb100%\u00bb _builder_version=\u00bb4.17.4″ header_font=\u00bbPT Sans|700|||||||\u00bb header_text_color=\u00bb#000000″ header_line_height=\u00bb25px\u00bb body_font=\u00bbPT Sans||||||||\u00bb body_text_color=\u00bb#000000″ body_font_size=\u00bb16px\u00bb body_line_height=\u00bb1.8em\u00bb text_orientation=\u00bbcenter\u00bb background_layout=\u00bbdark\u00bb custom_margin=\u00bb|||\u00bb custom_padding=\u00bb|||\u00bb animation_style=\u00bbslide\u00bb animation_direction=\u00bbbottom\u00bb animation_intensity_slide=\u00bb10%\u00bb animation=\u00bboff\u00bb link_option_url=\u00bbhttps:\/\/doi.org\/10.1016\/j.chemosphere.2020.129051″ link_option_url_new_window=\u00bbon\u00bb hover_enabled=\u00bb0″ global_colors_info=\u00bb{}\u00bb sticky_enabled=\u00bb0″]<\/p>\n

Endocrine disruptors in plastics alter \u03b2-cell physiology and increase the risk of diabetes mellitus.<\/span>
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American Journal of Physiology- Endocrinology and Metabolism 324(6):E488-E505. <\/b><\/p>\n

doi: 10.1152\/ajpendo.00068.2023. <\/b><\/p>\n

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Screening of Metabolism-Disrupting Chemicals on Pancreatic \u03b1-Cells Using In Vitro Methods.<\/span><\/p>\n

International Journal of Molecular Sciences. 24(1):231. <\/b><\/p>\n

doi: 10.3390\/ijms24010231.<\/b><\/p>\n

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BCL-XL Overexpression Protects Pancreatic \u03b2-Cells against Cytokine- and Palmitate-Induced Apoptosis.<\/span><\/p>\n

International Journal of Molecular Sciences. 2023 Mar 16;24(6):5657. <\/b><\/p>\n

doi: 10.3390\/ijms24065657.<\/b><\/p>\n

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G protein-coupled estrogen receptor activation by bisphenol-A disrupts the protection from apoptosis conferred by the estrogen receptors ER\u03b1 and ER\u03b2 in pancreatic beta cells.<\/p>\n

Environment International 164:107250<\/span><\/strong><\/p>\n

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In Vitro Assays to Identify Metabolism-Disrupting Chemicals with Diabetogenic Activity in a Human Pancreatic \u03b2-Cell Model.<\/p>\n

Int J Mol Sci. 23(9):5040<\/strong><\/p>\n

doi:10.3390\/ijms23095040<\/strong><\/p>\n

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[\/et_pb_blurb][et_pb_button button_url=\u00bbhttps:\/\/doi.org\/10.3390\/ijms23095040″ url_new_window=\u00bbon\u00bb button_text=\u00bbleer m\u00e1s\u00bb button_alignment=\u00bbcenter\u00bb _builder_version=\u00bb4.17.4″ custom_button=\u00bbon\u00bb button_text_size=\u00bb22px\u00bb button_text_color=\u00bb#333399″ button_border_width=\u00bb0px\u00bb button_border_radius=\u00bb0px\u00bb button_letter_spacing=\u00bb0px\u00bb button_font=\u00bbPT Sans|700||on|||||\u00bb button_on_hover=\u00bboff\u00bb custom_margin=\u00bb|||\u00bb custom_padding=\u00bb|||\u00bb global_colors_info=\u00bb{}\u00bb button_text_size__hover_enabled=\u00bboff\u00bb button_one_text_size__hover_enabled=\u00bboff\u00bb button_two_text_size__hover_enabled=\u00bboff\u00bb button_text_color__hover_enabled=\u00bboff\u00bb button_one_text_color__hover_enabled=\u00bboff\u00bb button_two_text_color__hover_enabled=\u00bboff\u00bb button_border_width__hover_enabled=\u00bboff\u00bb button_one_border_width__hover_enabled=\u00bboff\u00bb button_two_border_width__hover_enabled=\u00bboff\u00bb button_border_color__hover_enabled=\u00bboff\u00bb button_one_border_color__hover_enabled=\u00bboff\u00bb button_two_border_color__hover_enabled=\u00bboff\u00bb button_border_radius__hover_enabled=\u00bboff\u00bb button_one_border_radius__hover_enabled=\u00bboff\u00bb button_two_border_radius__hover_enabled=\u00bboff\u00bb button_letter_spacing__hover_enabled=\u00bboff\u00bb button_one_letter_spacing__hover_enabled=\u00bboff\u00bb button_two_letter_spacing__hover_enabled=\u00bboff\u00bb button_bg_color__hover_enabled=\u00bboff\u00bb button_one_bg_color__hover_enabled=\u00bboff\u00bb button_two_bg_color__hover_enabled=\u00bboff\u00bb][\/et_pb_button][\/et_pb_column][et_pb_column type=\u00bb1_3″ _builder_version=\u00bb4.16″ background_color=\u00bbrgba(255,255,255,0.39)\u00bb custom_padding=\u00bb30px|30px|30px|30px\u00bb box_shadow_style=\u00bbpreset1″ global_colors_info=\u00bb{}\u00bb custom_padding__hover=\u00bb|||\u00bb][et_pb_blurb title=\u00bbTudur\u00ed E, Soriano S, Almagro L, Garc\u00eda-Heredia A, Rafacho A, Alonso-Magdalena P, Nadal \u00c1, Quesada I. (2022)\u00bb content_max_width=\u00bb100%\u00bb _builder_version=\u00bb4.17.4″ header_font=\u00bbPT Sans|700|||||||\u00bb header_text_color=\u00bb#000000″ header_line_height=\u00bb25px\u00bb body_font=\u00bbPT Sans||||||||\u00bb body_text_color=\u00bbrgba(255,255,255,0.7)\u00bb body_font_size=\u00bb16px\u00bb body_line_height=\u00bb1.8em\u00bb text_orientation=\u00bbcenter\u00bb background_layout=\u00bbdark\u00bb custom_margin=\u00bb|||\u00bb custom_padding=\u00bb|||\u00bb animation_style=\u00bbslide\u00bb animation_direction=\u00bbbottom\u00bb animation_intensity_slide=\u00bb10%\u00bb animation=\u00bboff\u00bb global_colors_info=\u00bb{}\u00bb]The effects of aging on male mouse pancreatic \u03b2-cell function involve multiple events in the regulation of secretion: influence of insulin sensitivity.<\/span><\/p>\n

J Gerontol A Biol Sci Med Sci. 25: glab276 <\/span><\/strong><\/p>\n

doi: 10.1093\/gerona\/glab276<\/span><\/strong><\/p>\n

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The pancreatic \u03b2-cell in ageing: Implications in age-related diabetes.<\/span><\/p>\n

Ageing Res Rev. 80:101674.<\/span><\/strong><\/p>\n

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\ndoi: 10.1016\/j.chemosphere.2020.129051<\/strong><\/span><\/strong><\/p>\n

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\n<\/strong><\/span><\/strong>
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MIEMBROS<\/span><\/strong><\/span><\/h2>\n

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Investigador Principal<\/h5>\n

[\/et_pb_text][et_pb_button button_text=\u00bbANGEL NADAL\u00bb button_alignment=\u00bbcenter\u00bb module_class=\u00bbrv_button\u00bb _builder_version=\u00bb4.17.4″ custom_button=\u00bbon\u00bb button_text_size=\u00bb16px\u00bb button_text_color=\u00bb#ffffff\u00bb button_bg_color=\u00bb#333399″ button_border_color=\u00bb#333399″ button_border_radius=\u00bb13px\u00bb button_icon=\u00bbC||divi||400″ button_on_hover=\u00bboff\u00bb background_layout=\u00bbdark\u00bb global_colors_info=\u00bb{}\u00bb][\/et_pb_button][et_pb_text module_id=\u00bbreveal\u00bb _builder_version=\u00bb4.17.4″ _module_preset=\u00bbdefault\u00bb text_text_color=\u00bb#000000″ text_font_size=\u00bb16px\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n

Angel Nadal es catedr\u00e1tico de Fisiolog\u00eda y subdirector del IDiBE en la Universidad Miguel Hern\u00e1ndez de Elche y jefe de grupo y miembro del Comit\u00e9 de Direcci\u00f3n del CIBERDEM. Sus investigaciones han demostrado la relaci\u00f3n entre la exposici\u00f3n al Bisfenol-A y las alteraciones del metabolismo de la glucosa, incluyendo el estudio de los eventos moleculares iniciales. Estos hallazgos han sido fundamentales para establecer la relaci\u00f3n entre la exposici\u00f3n disruptores endocrinos y la diabetes mellitus. Su inter\u00e9s contin\u00faa en el estudio de c\u00f3mo el medio ambiente afecta a la divisi\u00f3n, muerte y funci\u00f3n de las c\u00e9lulas \u03b2 y su implicaci\u00f3n en el desarrollo de la diabetes. Ha sido reconocido con el premio de la Sociedad Espa\u00f1ola de Diabetes al mejor investigador joven (2004) y el premio Alberto Sols a la investigaci\u00f3n b\u00e1sica en diabetes (2017). Participa habitualmente en la mejora de la traslaci\u00f3n de la ciencia de los disruptores endocrinos a la regulaci\u00f3n.<\/span><\/p>\n

https:\/\/orcid.org\/0000-0003-4178-2152<\/span><\/a><\/p>\n

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Investigadora<\/h5>\n

[\/et_pb_text][et_pb_button button_text=\u00bbPALOMA ALONSO-MAGDALENA\u00bb button_alignment=\u00bbcenter\u00bb module_class=\u00bbrv_button3″ _builder_version=\u00bb4.17.4″ custom_button=\u00bbon\u00bb button_text_size=\u00bb14px\u00bb button_text_color=\u00bb#ffffff\u00bb button_bg_color=\u00bb#333399″ button_border_color=\u00bb#333399″ button_border_radius=\u00bb13px\u00bb button_icon=\u00bbC||divi||400″ button_on_hover=\u00bboff\u00bb background_layout=\u00bbdark\u00bb global_colors_info=\u00bb{}\u00bb][\/et_pb_button][et_pb_text module_id=\u00bbreveal3″ _builder_version=\u00bb4.17.4″ _module_preset=\u00bbdefault\u00bb text_text_color=\u00bb#000000″ text_font_size=\u00bb16px\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n

Paloma Alonso-Magdalena estudi\u00f3 Biolog\u00eda en la Universidad de Oviedo. Se doctor\u00f3 en la Universidad Miguel Hern\u00e1ndez. Posteriormente, fue investigadora postdoctoral en el Departamento de Nutrici\u00f3n del Instituto Karolinska, Estocolmo (Suecia) etapa en la que se centr\u00f3 en el estudio de la fisiolog\u00eda del receptor de estr\u00f3genos ER\u03b2. Asimismo, fue investigadora visitante en el Centro de Receptores Nucleares y Se\u00f1alizaci\u00f3n Celular en la Universidad de Houston (Estados Unidos). En la actualidad es profesora titular de Nutrici\u00f3n y Bromatolog\u00eda en la Universidad Miguel Hern\u00e1ndez e investigadora principal en IDiBE. Su investigaci\u00f3n se centra en comprender el papel de los disruptores endocrinos en la etiolog\u00eda de la diabetes, la obesidad y los des\u00f3rdenes metab\u00f3licos asociados. Su trabajo ha sido decisivo para establecer la relaci\u00f3n entre la exposici\u00f3n a ciertos disruptores endocrinos como el bisfenol y el origen de la diabetes tipo 2. Adem\u00e1s, su actividad cient\u00edfica se centra en el estudio de la fisiolog\u00eda y las adaptaciones metab\u00f3licas de las c\u00e9lulas alfa y beta del p\u00e1ncreas durante el embarazo; con especial inter\u00e9s en comprender las bases moleculares de la diabetes mellitus gestacional y en identificar las v\u00edas de se\u00f1alizaci\u00f3n alteradas que conducen al desarrollo de esta enfermedad. Fue galardonada con el premio de la Sociedad Espa\u00f1ola de Diabetes a la mejor investigadora joven (2018).<\/span><\/p>\n

https:\/\/orcid.org\/0000-0003-1065-5388<\/span><\/a><\/p>\n

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Investigadora<\/h5>\n

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Esther Fuentes estudi\u00f3 Bioqu\u00edmica en la Universidad de Valencia (Espa\u00f1a) y se doctor\u00f3 en el King’s College de Londres (Reino Unido). Es profesora de Nutrici\u00f3n y Bromatolog\u00eda en la Universidad Miguel Hern\u00e1ndez de Elche. Compagina su docencia y su inter\u00e9s investigador en el papel de los disruptores endocrinos en los trastornos metab\u00f3licos con su cargo de gesti\u00f3n como Vicerrectora adjunta de Cultura y Extensi\u00f3n en la UMH.<\/span><\/p>\n

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Investigador<\/h5>\n

[\/et_pb_text][et_pb_button button_text=\u00bbIV\u00c1N QUESADA\u00bb button_alignment=\u00bbcenter\u00bb module_class=\u00bbrv_button4″ _builder_version=\u00bb4.17.4″ custom_button=\u00bbon\u00bb button_text_size=\u00bb14px\u00bb button_text_color=\u00bb#ffffff\u00bb button_bg_color=\u00bb#333399″ button_border_width=\u00bb17px\u00bb button_border_color=\u00bb#333399″ button_border_radius=\u00bb18px\u00bb button_icon=\u00bbC||divi||400″ button_on_hover=\u00bboff\u00bb background_layout=\u00bbdark\u00bb global_colors_info=\u00bb{}\u00bb][\/et_pb_button][et_pb_text module_id=\u00bbreveal4″ _builder_version=\u00bb4.17.4″ _module_preset=\u00bbdefault\u00bb text_text_color=\u00bb#000000″ text_font_size=\u00bb16px\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n

Ivan Quesada es Catedr\u00e1tico de Nutrici\u00f3n en la Universidad Miguel Hern\u00e1ndez de Elche. Fue investigador postdoctoral en la Universidad de Washington en Seattle (2001-2003). Asimismo, el Dr. Quesada ha sido Profesor Visitante en la Universidad de Washington (2004). Sus estudios se han centrado en comprender las alteraciones, adaptaciones y\/o fallos de las c\u00e9lulas alfa y beta del p\u00e1ncreas en condiciones fisiol\u00f3gicas como el embarazo y el envejecimiento, as\u00ed como en condiciones patol\u00f3gicas como la obesidad y la diabetes. Su investigaci\u00f3n en los \u00faltimos a\u00f1os ha contribuido principalmente a una mejor comprensi\u00f3n de la biolog\u00eda de las c\u00e9lulas alfa pancre\u00e1ticas en la salud y la enfermedad, y su contribuci\u00f3n a la diabetes. Fue premiado por la Sociedad Espa\u00f1ola de Diabetes como mejor investigador joven (2008).<\/span><\/p>\n

https:\/\/orcid.org\/0000-0002-9808-514X<\/span><\/a><\/p>\n

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DIABESITY AND ISLET REARCH LABProyecto PrometeoOBJETIVOS1 Estudiar el papel de la activaci\u00f3n de los receptores de estr\u00f3genos en ER\u03b2 y GPER\u00a0en la viabilidad de la c\u00e9lula-\u03b2 en presencia y ausencia de est\u00edmulos apopt\u00f3ticos.2 Analizar el efecto de la disminuci\u00f3n de la expresi\u00f3n de los receptores de estr\u00f3genos ER\u03b2 y GPER, usando RNA de interferencia, en […]<\/p>\n","protected":false},"author":3158,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"

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DIABESITY AND ISLET REARCH LAB<\/span><\/p>

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Projecte Prometeu<\/span><\/strong><\/h1>

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OBJECTIUS<\/span><\/strong><\/span><\/h2>

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_5,3_5,1_5\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_column type=\"1_5\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_text _builder_version=\"4.17.4\" _module_preset=\"default\" text_text_color=\"#ab1a2d\" text_font_size=\"100px\" header_font=\"|700|||||||\" header_font_size=\"100px\" header_line_height=\"1.2em\" header_2_text_color=\"#ab1a2d\" header_2_font_size=\"100px\" header_2_line_height=\"1.2em\" custom_margin=\"|||32px|false|false\" border_width_right=\"3px\" border_color_right=\"#333399\" global_colors_info=\"{}\"]<\/p>

1<\/strong><\/span><\/h2>

[\/et_pb_text][\/et_pb_column][et_pb_column type=\"3_5\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_text _builder_version=\"4.17.4\" _module_preset=\"default\" text_text_color=\"#000000\" text_font_size=\"16px\" custom_padding=\"25px||||false|false\" global_colors_info=\"{}\"]<\/p>

Estudiar el paper de l'activaci\u00f3 dels receptors d'estr\u00f2gens ER\u03b2 i GPER en la viabilitat de la c\u00e8l\u00b7lula-\u03b2 en pres\u00e8ncia i abs\u00e8ncia d'est\u00edmuls apopt\u00f2tics.<\/strong><\/span><\/p>

[\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_5\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_5,3_5,1_5\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_column type=\"1_5\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_text _builder_version=\"4.17.4\" _module_preset=\"default\" text_text_color=\"#ab1a2d\" text_font_size=\"100px\" header_font=\"|700|||||||\" header_font_size=\"100px\" header_line_height=\"1.2em\" header_2_text_color=\"#ab1a2d\" header_2_font_size=\"100px\" header_2_line_height=\"1.2em\" custom_margin=\"|||32px|false|false\" border_width_right=\"3px\" border_color_right=\"#333399\" global_colors_info=\"{}\"]<\/p>

2<\/strong><\/span><\/h2>

[\/et_pb_text][\/et_pb_column][et_pb_column type=\"3_5\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_text _builder_version=\"4.17.4\" _module_preset=\"default\" text_text_color=\"#000000\" text_font_size=\"16px\" width=\"99.8%\" custom_padding=\"25px||||false|false\" global_colors_info=\"{}\"]<\/p>

Analitzar l'efecte de la disminuci\u00f3 de l'expressi\u00f3 dels receptors d'estr\u00f2gens ER\u03b2 i GPER<\/strong>, utilitzant RNA d'interfer\u00e8ncia, en la viabilitat cel\u00b7lular.<\/p>

[\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_5\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_5,3_5,1_5\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_column type=\"1_5\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_text _builder_version=\"4.17.4\" _module_preset=\"default\" text_text_color=\"#ab1a2d\" text_font_size=\"100px\" header_font=\"|700|||||||\" header_font_size=\"100px\" header_line_height=\"1.2em\" header_2_text_color=\"#ab1a2d\" header_2_font_size=\"100px\" header_2_line_height=\"1.2em\" custom_margin=\"|||32px|false|false\" border_width_right=\"3px\" border_color_right=\"#333399\" global_colors_info=\"{}\"]<\/p>

3<\/strong><\/span><\/h2>

[\/et_pb_text][\/et_pb_column][et_pb_column type=\"3_5\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_text _builder_version=\"4.17.4\" _module_preset=\"default\" text_text_color=\"#000000\" text_font_size=\"16px\" custom_padding=\"25px||||false|false\" global_colors_info=\"{}\"]<\/p>

Caracteritzaci\u00f3 del paper de ER\u03b2 i GPER en la secreci\u00f3 de glucag\u00f3<\/strong>, i en la viabilitat cel\u00b7lular de la c\u00e8l\u00b7lula-\u03b1.<\/p>

[\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_5\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\"4.16\" global_colors_info=\"{}\"][et_pb_column type=\"4_4\" _builder_version=\"4.16\" global_colors_info=\"{}\"][et_pb_image src=\"https:\/\/dialab.umh.es\/files\/2022\/10\/icono-1.png\" align=\"center\" _builder_version=\"4.17.4\" global_colors_info=\"{}\"][\/et_pb_image][et_pb_text _builder_version=\"4.17.4\" text_font=\"|300|||||||\" text_text_color=\"#000000\" text_font_size=\"19px\" text_line_height=\"1.8em\" header_2_font=\"|600|||||||\" header_2_text_color=\"#8c0000\" header_2_font_size=\"30px\" header_2_line_height=\"1.2em\" global_colors_info=\"{}\"]<\/p>

Regulaci\u00f3 de la viabilitat i la funci\u00f3 de les c\u00e8l\u00b7lules \u03b2 i \u03b1 pancre\u00e0tiques pels receptors d'estr\u00f2gens ER\u03b2 i GPER: paper en la ter\u00e0pia de la diabetis mellitus<\/strong><\/p>

El 17\u03b2-estradiol (E2) \u00e9s una hormona sexual produ\u00efda per la c\u00e8l\u00b7lula de les granuloses en l'ovari, que est\u00e0 tradicionalment implicada en la diferenciaci\u00f3 sexual, la pubertat i la reproducci\u00f3. En les dues \u00faltimes d\u00e8cades l'impacte de l'E2 ha transcendit a moltes altres funcions fisiol\u00f2giques, entre elles, l'home\u00f2stasi de la glucosa, incloent els seus efectes en les c\u00e8l\u00b7lules \u03b2 i \u03b1 del p\u00e0ncrees endocr\u00ed. L'E2 regula el contingut d'insulina i la seua secreci\u00f3 en resposta a la glucosa, i produeix l'efecte contrari en el cas de la c\u00e8l\u00b7lula-\u03b1 i la secreci\u00f3 de glucag\u00f3. Tamb\u00e9 protegeix la c\u00e8l\u00b7lula-\u03b2 de la mort cel\u00b7lular en resposta a est\u00edmuls apopt\u00f2tics i no es sap si fa el mateix en la c\u00e8l\u00b7lula-\u03b1. El paper del receptor d'estr\u00f2gens ER\u03b1 en la funci\u00f3 i la superviv\u00e8ncia de la c\u00e8l\u00b7lula-\u03b2 est\u00e0 relativament ben estudiat. No ocorre igual amb els altres dos receptors d'estr\u00f2gens, ER\u03b2 i GPER. La dissecci\u00f3 dels mecanismes d'acci\u00f3 de l'E2 a trav\u00e9s dels receptors d'estr\u00f2gens ER\u03b2 i GPER en el p\u00e0ncrees endocr\u00ed que proposem en aquest projecte, ens ajudaren a con\u00e8ixer millor les difer\u00e8ncies de sexe en l'home\u00f2stasi de la glucosa. Aquest coneixement ajudar\u00e0 a millorar el tractament de la diabetis mellitus tipus 2, els efectes secundaris de la hormonoter\u00e0pia per a determinats tipus de c\u00e0ncers dependents d\u2019hormones i a comprendre la fisiologia transg\u00e8nere.<\/p>

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PUBLICACIONS<\/span><\/strong><\/span><\/h2>

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_3,1_3,1_3\" use_custom_gutter=\"on\" gutter_width=\"2\" make_equal=\"on\" _builder_version=\"4.16\" max_width=\"100%\" global_colors_info=\"{}\"][et_pb_column type=\"1_3\" _builder_version=\"4.16\" background_color=\"rgba(255,255,255,0.39)\" custom_padding=\"30px|30px|30px|30px\" box_shadow_style=\"preset1\" global_colors_info=\"{}\" custom_padding__hover=\"|||\"][et_pb_blurb title=\"Marroqui L, Martinez-Pinna J, Castellano-Mu\u00f1oz M, Dos Santos RS, Medina-Gali RM, Soriano S, Quesada I, Gustafsson JA, Encinar JA, Nadal A. (2021)\" url_new_window=\"on\" content_max_width=\"100%\" _builder_version=\"4.17.4\" header_font=\"PT Sans|700|||||||\" header_text_color=\"#000000\" header_line_height=\"25px\" body_font=\"PT Sans||||||||\" body_text_color=\"#000000\" body_font_size=\"16px\" body_line_height=\"1.8em\" text_orientation=\"center\" background_layout=\"dark\" custom_margin=\"|||\" custom_padding=\"|||\" animation_style=\"slide\" animation_direction=\"bottom\" animation_intensity_slide=\"10%\" animation=\"off\" link_option_url=\"https:\/\/doi.org\/10.1016\/j.chemosphere.2020.129051\" link_option_url_new_window=\"on\" global_colors_info=\"{}\"]<\/p>

Bisphenol-S and Bisphenol-F alter mouse pancreatic \u03b2-cell ion channel expression and activity and insulin release through an estrogen receptor ER\u03b2 mediated pathway<\/p>

doi: 10.1016\/j.chemosphere.2020.129051<\/strong><\/span><\/strong><\/p>

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\u00a0<\/p>

G protein-coupled estrogen receptor activation by bisphenol-A disrupts the protection from apoptosis conferred by the estrogen receptors ER\u03b1 and ER\u03b2 in pancreatic beta cells.<\/p>

Environment International 164:107250<\/span><\/strong><\/p>

doi:\u00a010.1016\/j.envint.2022.107250<\/strong><\/span><\/strong>\u00a0<\/p>

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In Vitro Assays to Identify Metabolism-Disrupting Chemicals with Diabetogenic Activity in a Human Pancreatic \u03b2-Cell Model.<\/p>

Int J Mol Sci. 23(9):5040<\/strong><\/p>

doi:10.3390\/ijms23095040<\/strong><\/p>

\u00a0<\/p>

\u00a0<\/p>

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J Gerontol A Biol Sci Med Sci. 25: glab276 <\/span><\/strong><\/p>

doi: 10.1093\/gerona\/glab276<\/span><\/strong><\/p>

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The pancreatic \u03b2-cell in ageing: Implications in age-related diabetes.<\/span><\/p>

Ageing Res Rev. 80:101674.<\/span><\/strong><\/p>

doi:\u00a010.1016\/j.arr.2022.101674<\/strong><\/span><\/strong><\/p>

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\u00a0<\/p>

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MEMBRES<\/span><\/strong><\/span><\/h2>

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Investigador Principal<\/h5>

[\/et_pb_text][et_pb_button button_text=\"ANGEL NADAL\" button_alignment=\"center\" module_class=\"rv_button\" _builder_version=\"4.17.4\" custom_button=\"on\" button_text_color=\"#ffffff\" button_bg_color=\"#333399\" button_border_color=\"#333399\" button_border_radius=\"13px\" background_layout=\"dark\" global_colors_info=\"{}\"][\/et_pb_button][et_pb_text module_id=\"reveal\" _builder_version=\"4.17.4\" _module_preset=\"default\" text_text_color=\"#000000\" text_font_size=\"16px\" global_colors_info=\"{}\"]<\/p>

\u00c1ngel Nadal \u00e9s catedr\u00e0tic de Fisiologia i subdirector del IDiBE en la Universitat Miguel Hern\u00e1ndez d'Elx i cap de grup i membre del Comit\u00e9 de Direcci\u00f3 del CIBERDEM. Les seues investigacions han demostrat la relaci\u00f3 entre l'exposici\u00f3 al Bisfenol-A i les alteracions del metabolisme de la glucosa, incloent l'estudi dels esdeveniments moleculars inicials. Aquestos resultats han sigut fonamentals per a establir la relaci\u00f3 entre l'exposici\u00f3 als disruptors endocrins i la diabetis mellitus. El seu inter\u00e9s continua en l'estudi de com el medi ambient afecta a la divisi\u00f3, mort i funci\u00f3 de les c\u00e8l\u00b7lules -\u03b2 i la seua implicaci\u00f3 en el desenvolupament de la diabetis. Ha sigut reconegut amb el premi de la Societat Espanyola de Diabetis al millor investigador jove (2004) i el premi Alberto Sols a la investigaci\u00f3 b\u00e0sica en diabetis (2017). Participa habitualment en la millora de la translaci\u00f3 de la ci\u00e8ncia dels disruptors endocrins a la regulaci\u00f3.
https:\/\/orcid.org\/0000-0003-4178-2152<\/span><\/a><\/span><\/p>

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Investigadora<\/h5>

[\/et_pb_text][et_pb_button button_text=\"PALOMA ALONSO-MAGDALENA\" button_alignment=\"center\" module_class=\"rv_button3\" _builder_version=\"4.17.4\" custom_button=\"on\" button_text_size=\"16px\" button_text_color=\"#ffffff\" button_bg_color=\"#333399\" button_border_color=\"#333399\" button_border_radius=\"13px\" button_icon=\";||divi||400\" button_on_hover=\"off\" background_layout=\"dark\" hover_enabled=\"0\" global_colors_info=\"{}\" sticky_enabled=\"0\"][\/et_pb_button][et_pb_text module_id=\"reveal3\" _builder_version=\"4.17.4\" _module_preset=\"default\" text_text_color=\"#000000\" text_font_size=\"16px\" global_colors_info=\"{}\"]<\/p>

Paloma Alonso-Magdalena va estudiar Biologia a la Universitat d'Oviedo. Va obtenir el seu doctorat a la Universitat Miguel Hern\u00e1ndez i va realitzar una estada postdoctoral al Departament de Nutrici\u00f3 del Karolinska Institutet d'Estocolm (Su\u00e8cia) on va estudiar la fisiologia del receptor d'estr\u00f2gens ER\u03b2. Tamb\u00e9 va ser investigadora visitant al Center for Nuclear Receptors and Cell Signaling de Houston (EUA). Actualment \u00e9s professora de Nutrici\u00f3 i Bromatologia de la Universitat Miguel Hern\u00e1ndez d'Elx i investigadora principal de l'IDiBE. La seva investigaci\u00f3 se centra a entendre el paper que tenen els disruptius endocrins (EDC) en l'etiologia de la diabetis, l'obesitat i els trastorns metab\u00f2lics relacionats. El seu treball ha estat decisiu per vincular l'exposici\u00f3 a certs disruptors endocrins generalitzats com el bisfenol-A amb l'etiopatologia de la diabetis tipus 2. A m\u00e9s, est\u00e0 interessada en la fisiologia i les adaptacions metab\u00f2liques de les c\u00e8l\u00b7lules alfa i beta pancre\u00e0tiques durant l'embar\u00e0s. Est\u00e0 especialment centrada en la comprensi\u00f3 de les bases moleculars de la diabetis mellitus gestacional i la identificaci\u00f3 de vies de senyalitzaci\u00f3 alterades que condueixen al desenvolupament d'aquesta malaltia. Va ser guardonada amb el premi de la Societat Espanyola de Diabetis a la millor investigadora jove (2018)
https:\/\/orcid.org\/0000-0003-1065-5388<\/a><\/span><\/p>

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Investigadora<\/h5>

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Esther Fuentes va estudiar Bioqu\u00edmica en la Universitat de Val\u00e8ncia (Espanya) i es va doctorar en el King's College de Londres (Regne Unit). \u00c9s professora de Nutrici\u00f3 i Bromatologia en la Universitat Miguel Hern\u00e1ndez d'Elx. Compagina el seu inter\u00e9s investigador en el paper dels disruptors endocrins en els trastorns metab\u00f2lics amb el seu c\u00e0rrec de Vicerectora adjunta de Cultura.<\/p>

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Investigador<\/h5>

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Ivan Quesada \u00e9s catedr\u00e0tic de Nutrici\u00f3 de la Universitat Miguel Hern\u00e1ndez d'Elx. Va obtenir el seu doctorat a la Universitat Miguel Hern\u00e1ndez (2000) i va realitzar una estada postdoctoral a la Universitat de Washington a Seattle (2001-2003). El Dr. Quesada tamb\u00e9 va ser convidat com a Visiting Assistant Professor per ensenyar a la Universitat de Washington (2004). Els seus estudis s'han centrat en entendre les alteracions, adaptacions i\/o fallades de les c\u00e8l\u00b7lules alfa i beta pancre\u00e0tiques en condicions fisiol\u00f2giques com l'embar\u00e0s i l'envelliment, aix\u00ed com en condicions patol\u00f2giques com l'obesitat i la diabetis. La seva investigaci\u00f3 en els darrers anys ha contribu\u00eft principalment a una millor comprensi\u00f3 de la biologia de les c\u00e8l\u00b7lules alfa pancre\u00e0tiques en salut i malaltia, i la seva contribuci\u00f3 a la diabetis. Va ser guardonat per la Societat Espanyola de Diabetis al millor investigador jove (2008).
https:\/\/orcid.org\/0000-0002-9808-514X<\/a><\/span><\/p>

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