{"id":703,"date":"2022-11-25T09:53:00","date_gmt":"2022-11-25T08:53:00","guid":{"rendered":"https:\/\/dialab.umh.es\/?page_id=703"},"modified":"2026-01-21T14:17:03","modified_gmt":"2026-01-21T13:17:03","slug":"inicio","status":"publish","type":"page","link":"https:\/\/dialab.umh.es\/es\/","title":{"rendered":"Inicio"},"content":{"rendered":"

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D<\/strong><\/span>IALAB<\/span><\/span><\/h1>\n

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DIABESITY<\/span><\/h1>\n

AND<\/span><\/h1>\n

ISLET RESEARCH LAB<\/span><\/h1>\n

\u00a0<\/span>
\n[\/et_pb_text][\/et_pb_column][et_pb_column type=\u00bb2_3″ _builder_version=\u00bb4.17.4″ _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_image src=\u00bbhttps:\/\/dialab.umh.es\/files\/2022\/11\/islote-3D-4.png\u00bb title_text=\u00bbislote 3D 4″ _builder_version=\u00bb4.17.4″ _module_preset=\u00bbdefault\u00bb max_width=\u00bb48%\u00bb module_alignment=\u00bbcenter\u00bb border_radii=\u00bbon|270px|270px|270px|270px\u00bb global_colors_info=\u00bb{}\u00bb][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\u00bb1″ _builder_version=\u00bb4.17.4″ _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_row _builder_version=\u00bb4.17.4″ _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb4_4″ _builder_version=\u00bb4.17.4″ _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_text _builder_version=\u00bb4.17.4″ _module_preset=\u00bbdefault\u00bb header_2_font=\u00bb|700|||||||\u00bb header_2_font_size=\u00bb35px\u00bb header_2_line_height=\u00bb1.2em\u00bb border_color_top=\u00bb#ffffff\u00bb border_width_bottom=\u00bb9px\u00bb border_color_bottom=\u00bb#333399″ global_colors_info=\u00bb{}\u00bb]<\/p>\n

Comprometidos en la comprensi\u00f3n de los mecanismos que subyacen a la carga combinada de la diabetes y la obesidad<\/h2>\n

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Nuestro laboratorio se dedica a mejorar la comprensi\u00f3n sobre la fisiopatolog\u00eda de la diabetes y los trastornos metab\u00f3licos relacionados con ella, mediante el estudio de los factores de riesgo y los mecanismos celulares y moleculares subyacentes. El objetivo final es determinar nuevas dianas moleculares y contribuir a desarrollar estrategias terap\u00e9uticas y de prevenci\u00f3n. Nuestros estudios se centran principalmente en las c\u00e9lulas beta y alfa del p\u00e1ncreas, pero tambi\u00e9n en otros tejidos implicados en la homeostasis de la glucosa.<\/p>\n

[\/et_pb_text][et_pb_button button_text=\u00bbLEER M\u00c1S\u00bb button_alignment=\u00bbcenter\u00bb module_class=\u00bbrv_button\u00bb _builder_version=\u00bb4.17.4″ custom_button=\u00bbon\u00bb button_text_size=\u00bb22px\u00bb button_text_color=\u00bb#ffffff\u00bb button_bg_color=\u00bb#333399″ button_border_color=\u00bb#333399″ button_border_radius=\u00bb13px\u00bb button_icon=\u00bb;||divi||400″ background_layout=\u00bbdark\u00bb global_colors_info=\u00bb{}\u00bb][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row module_id=\u00bbreveal\u00bb _builder_version=\u00bb4.17.4″ _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb4_4″ _builder_version=\u00bb4.17.4″ _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_text _builder_version=\u00bb4.17.4″ _module_preset=\u00bbdefault\u00bb text_font=\u00bbRoboto|700|||||||\u00bb header_font_size=\u00bb50px\u00bb header_3_font_size=\u00bb30px\u00bb custom_margin=\u00bb36px||||false|false\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n

NUESTRAS PRINCIPALES L\u00cdNEAS DE INVESTIGACI\u00d3N SON:<\/h3>\n

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Descifrando los mecanismos implicados en la etiolog\u00eda de la diabetes mellitus gestacional (DMG) y su implicaci\u00f3n en el desarrollo posterior de la diabetes:<\/h3>\n

\u00a0<\/h1>\n

\u00a0<\/span><\/p>\n

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La DMG es el trastorno metab\u00f3lico m\u00e1s com\u00fan que tiene lugar durante el embarazo. Su incidencia aumenta r\u00e1pidamente en todo el mundo convirti\u00e9ndose en un problema prioritario para la salud p\u00fablica. La DMG es mucho m\u00e1s que la aparici\u00f3n de hiperglucemia en la madre de forma transitoria durante el embarazo. Predispone a la madre y a la descendencia, tanto masculina como femenina, a un mayor riesgo de desarrollar diabetes de tipo 2 y obesidad en el futuro. Por ello, la comprensi\u00f3n de los mecanismos subyacentes a la DMG contribuir\u00e1 a contener la actual epidemia de diabesidad. Utilizando modelos de experimentaci\u00f3n in vivo e in vitro, buscamos comprender las bases moleculares de la DMG, con especial \u00e9nfasis en la obesidad como factor de riesgo, e identificar las v\u00edas de se\u00f1alizaci\u00f3n alteradas que conducen al desarrollo de esta enfermedad. Adem\u00e1s, pretendemos explorar posibles herramientas terap\u00e9uticas que puedan presentar efectos beneficiosos en la prevenci\u00f3n y el control de la DMG.<\/p>\n

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Comprendiendo el papel de los disruptores qu\u00edmicos metab\u00f3licos en la aparici\u00f3n de trastornos metab\u00f3licos:<\/h3>\n

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Los disruptores endocrinos (DEs) son sustancias qu\u00edmicas que pueden interferir en el funcionamiento normal del sistema endocrino. Los DEs, presentes de manera ubicua, pueden encontrarse en una gran variedad de productos de consumo, como materiales de envasado de alimentos, productos de cuidado personal y del hogar, aditivos pl\u00e1sticos y retardantes de llama. Entre ellos, se ha demostrado que un subconjunto que recibe el nombre de disruptores qu\u00edmicos metab\u00f3licos, puede aumentar la incidencia de trastornos metab\u00f3licos, como la diabetes, la obesidad y el s\u00edndrome metab\u00f3lico, entre otros. Estudiamos c\u00f3mo la exposici\u00f3n a estos compuestos puede afectar a los procesos moleculares y celulares del p\u00e1ncreas endocrino. Adem\u00e1s, trabajamos para desarrollar m\u00e9todos nuevos y eficaces para identificar disruptores con efectos diabetog\u00e9nicos, obesog\u00e9nicos o diabesog\u00e9nicos. Esto contribuir\u00e1 a implementar nuevos m\u00e9todos de identificaci\u00f3n acordes con las necesidades regulatorias.<\/p>\n

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DIALAB DIABESITY AND ISLET RESEARCH LAB \u00a0 Comprometidos en la comprensi\u00f3n de los mecanismos que subyacen a la carga combinada de la diabetes y la obesidadNuestro laboratorio se dedica a mejorar la comprensi\u00f3n sobre la fisiopatolog\u00eda de la diabetes y los trastornos metab\u00f3licos relacionados con ella, mediante el estudio de los factores de riesgo y […]<\/p>\n","protected":false},"author":3158,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"

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D<\/strong><\/span>IALAB<\/span><\/span><\/h1>

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DIABESITY<\/span><\/h1>

AND<\/span><\/h1>

ISLET RESEARCH LAB<\/span><\/h1>

\u00a0<\/span><\/p>

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Committed to understanding the combined burden of diabetes and obesity<\/h2>

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Our laboratory is dedicated to better understanding the pathophysiology of diabetes and related disorders by focusing on the study of risk factors as well as the cellular and molecular mechanisms behind. The ultimate goal is to determine new molecular targets and contribute to develop therapeutic and prevention strategies. Our studies are mainly focused on the pancreatic beta and alpha-cells, but also in other tissues involved in glucose homeostasis.<\/span><\/p>

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OUR PRINCIPAL RESEARCH LINES ARE:<\/h3>

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Deciphering the mechanisms involved in the etiology of gestational diabetes mellitus (GDM) and its implication in the later development of diabetes:<\/span><\/h3>

\u00a0<\/h1>

\u00a0<\/span><\/p>

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GDM is the most common metabolic disorder of pregnancy. Its incidence is rapidly increasing all over the world and has become a public health priority issue. GDM is much more than a transient maternal hyperglycaemia occurring during pregnancy. It predisposes the mother and the offspring, both male and female, for increased risk of developing type 2 diabetes and obesity in the future. Thus, understanding the mechanisms underlying GDM will contribute to contain existing worldwide diabesity epidemic. Using in vivo and in vitro models we aim to understand the molecular basis of GDM, with particular emphasis on obesity as risk factor, and identify altered signaling pathways leading to the development of this disease. Furthermore, we aim to explore potential therapeutic tools which may present beneficial effects in the prevention and control of GDM.<\/p>

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Understanding the role of metabolism-disrupting chemicals in the occurrence of metabolic disorders:<\/span><\/h3>

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Endocrine-disrupting chemicals (EDCs) are chemical substances that can interfere with the normal function of the endocrine system. EDCs are ubiquitous and can be found in a variety of consumer products such as food packaging materials, personal care and household products, plastic additives, and flame retardants. Among them, a subset called metabolism-disrupting chemicals (MDCs) has been largely acknowledged to increase the incidence of metabolic disorders including diabetes, obesity and metabolic syndrome, among others. We study how exposure to MDCs may affect the molecular and cellular processes of the endocrine pancreas. In addition, we work to develop new and effective methods to identify EDCs with diabetogenic, obesogenic or diabesogenic effects. This will contribute to implement new testing approaches in line with the regulatory needs.<\/p>

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