{"id":745,"date":"2022-11-25T13:18:09","date_gmt":"2022-11-25T12:18:09","guid":{"rendered":"https:\/\/dialab.umh.es\/?page_id=745"},"modified":"2026-01-21T14:29:29","modified_gmt":"2026-01-21T13:29:29","slug":"inici","status":"publish","type":"page","link":"https:\/\/dialab.umh.es\/ca\/","title":{"rendered":"Inici"},"content":{"rendered":"

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D<\/strong><\/span>IALAB<\/span><\/span><\/h1>\n

[\/et_pb_text][et_pb_text _builder_version=”4.17.4″ _module_preset=”default” text_font=”Roboto|700|||||||” header_font=”|||on|||||” header_text_align=”left” header_text_color=”#007FE0″ header_font_size=”32px” header_line_height=”1.2em” height=”187px” custom_margin=”|||6px|false|false” custom_padding=”|||19px|false|false” border_color_all=”#FFFFFF” border_color_bottom=”RGBA(255,255,255,0)” border_width_left=”9px” global_colors_info=”{}”]<\/p>\n

DIABESITY<\/span><\/h1>\n

AND<\/span><\/h1>\n

ISLET RESEARCH LAB<\/span><\/h1>\n

\u00a0<\/span>
\n[\/et_pb_text][\/et_pb_column][et_pb_column type=”2_3″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/dialab.umh.es\/files\/2022\/11\/islote-3D-4.png” title_text=”islote 3D 4″ _builder_version=”4.17.4″ _module_preset=”default” max_width=”48%” module_alignment=”center” border_radii=”on|270px|270px|270px|270px” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_row _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.17.4″ _module_preset=”default” header_2_font=”|700|||||||” header_2_font_size=”35px” header_2_line_height=”1.2em” border_color_top=”#ffffff” border_width_bottom=”9px” border_color_bottom=”#333399″ global_colors_info=”{}”]<\/p>\n

Compromesos a comprendre els mecanismes subjacents a la c\u00e0rrega combinada de la diabetis i l’obesitat<\/h2>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.17.4″ _module_preset=”default” text_font=”Roboto|300|||||||” text_font_size=”19px” text_line_height=”1.8em” global_colors_info=”{}”]<\/p>\n

El nostre laboratori es dedica a millorar la comprensi\u00f3 sobre la fisiopatologia de la diabetis i els trastorns metab\u00f2lics relacionats amb ella, mitjan\u00e7ant l’estudi dels factors de risc i els mecanismes cel\u00b7lulars i moleculars subjacents. L’objectiu final \u00e9s determinar noves dianes moleculars i contribuir a desenvolupar estrat\u00e8gies terap\u00e8utiques i de prevenci\u00f3. Els nostres estudis se centren principalment en les c\u00e8l\u00b7lules beta i alfa del p\u00e0ncrees, per\u00f2 tamb\u00e9 en altres teixits implicats en l’home\u00f2stasi de la glucosa.<\/p>\n

[\/et_pb_text][et_pb_button button_text=”M\u00c9S INFORMACI\u00d3” button_alignment=”center” module_class=”rv_button” _builder_version=”4.17.4″ custom_button=”on” button_text_size=”22px” button_text_color=”#ffffff” button_bg_color=”#333399″ button_border_color=”#333399″ button_border_radius=”13px” button_icon=”;||divi||400″ background_layout=”dark” global_colors_info=”{}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row module_id=”reveal” _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.17.4″ _module_preset=”default” text_font=”Roboto|700|||||||” header_font_size=”50px” header_3_font_size=”30px” custom_margin=”36px||||false|false” global_colors_info=”{}”]<\/p>\n

LES NOSTRES PRINCIPALS L\u00cdNIES DE RECERCA S\u00d3N:<\/h3>\n

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Desxifrar els mecanismes implicats en l’etiologia de la diabetis mellitus gestacional (DMG) i la seva implicaci\u00f3 en el desenvolupament posterior de la diabetis:<\/h3>\n

\u00a0<\/h1>\n

\u00a0<\/span><\/p>\n

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La DMG \u00e9s el trastorn metab\u00f2lic m\u00e9s com\u00fa que t\u00e9 lloc durant l’embar\u00e0s. La seua incid\u00e8ncia augmenta r\u00e0pidament a tot el m\u00f3n convertint-se en un problema prioritari per a la salut p\u00fablica. La DMG \u00e9s molt m\u00e9s que l’aparici\u00f3 de hiperglucemia en la mare de manera transit\u00f2ria durant l’embar\u00e0s. Predisposa a la mare i a la descend\u00e8ncia, tant masculina com femenina, a un major risc de desenvolupar diabetis de tipus 2 i obesitat en el futur. Per aix\u00f2, la comprensi\u00f3 dels mecanismes subjacents a la DMG contribuir\u00e0 a contindre l’actual epid\u00e8mia de diabesidad. Utilitzant models d’experimentaci\u00f3 in vivo i in vitro, busquem comprendre les bases moleculars de la DMG, amb especial \u00e8mfasi en l’obesitat com a factor de risc, i identificar les vies de senyalitzaci\u00f3 alterades que condueixen al desenvolupament d’aquesta malaltia. A m\u00e9s, pretenem explorar possibles eines terap\u00e8utiques que puguen presentar efectes beneficiosos en la prevenci\u00f3 i el control de la DMG.<\/p>\n

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Comprendre el paper dels disruptors qu\u00edmics metab\u00f2lics en l’aparici\u00f3 de trastorns metab\u00f2lics:<\/h3>\n

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Els disruptors endocrins (DEs) s\u00f3n subst\u00e0ncies qu\u00edmiques que poden interferir en el funcionament normal del sistema endocr\u00ed. Els DEs, presents de manera ubiqua, poden trobar-se en una gran varietat de productes de consum, com a materials d’envasament d’aliments, productes de cura personal i de la llar, additius pl\u00e0stics i retardants de flama. Entre ells, s’ha demostrat que un subconjunt que rep el nom de disruptors qu\u00edmics metab\u00f2lics, pot augmentar la incid\u00e8ncia de trastorns metab\u00f2lics, com la diabetis, l’obesitat i la s\u00edndrome metab\u00f2lica, entre altres. Estudiem com l’exposici\u00f3 a aquests compostos pot afectar els processos moleculars i cel\u00b7lulars del p\u00e0ncrees endocr\u00ed. A m\u00e9s, treballem per a desenvolupar nous i efica\u00e7os m\u00e8todes per a identificar disruptors amb efectes diabetog\u00e8nics, obesog\u00e8nics o diabesog\u00e8nics. Aix\u00f2 contribuir\u00e0 a implementar nous m\u00e8todes d’identificaci\u00f3 concordes amb les necessitats reguladores.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,1_3,1_3″ make_equal=”on” _builder_version=”4.17.4″ _module_preset=”default” max_width=”1307px” custom_css_main_element=”align-items: center;” global_colors_info=”{}” locked=”off”][et_pb_column type=”1_3″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/dialab.umh.es\/files\/2022\/10\/MICINN-logo.png” alt=”Logo MICINN” title_text=”Logo MICINN” url=”https:\/\/www.ciencia.gob.es\/” url_new_window=”on” align=”center” _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/dialab.umh.es\/files\/2022\/10\/logo-gva-proyecto-prometeo.png” alt=”Logo Prometeo GV” title_text=”logo-gva-proyecto-prometeo” url=”https:\/\/isletcellsignal.umh.es\/prometeo-project\/” align=”center” _builder_version=”4.17.4″ _module_preset=”default” max_width=”65%” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/dialab.umh.es\/files\/2026\/01\/ciberdem.png” alt=”Logo Ciberdem” title_text=”ciberdem” url=”https:\/\/www.ciberdem.org\/” url_new_window=”on” align=”center” _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ make_equal=”on” _builder_version=”4.17.4″ _module_preset=”default” max_width=”1307px” custom_css_main_element=”align-items: center;” global_colors_info=”{}” disabled_on=”on|on|on” disabled=”on”][et_pb_column type=”1_4″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/dialab.umh.es\/files\/2022\/10\/oberon.jpeg” alt=”Logo Goliath” title_text=”oberon” url=”https:\/\/beatinggoliath.eu\/” url_new_window=”on” _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/dialab.umh.es\/files\/2022\/10\/MICINN-logo.png” alt=”Logo MICINN” title_text=”Logo MICINN” url=”https:\/\/www.ciencia.gob.es\/” url_new_window=”on” _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/dialab.umh.es\/files\/2022\/10\/logo-gva-proyecto-prometeo.png” alt=”Logo Prometeo GV” title_text=”logo-gva-proyecto-prometeo” url=”https:\/\/isletcellsignal.umh.es\/prometeo-project\/” _builder_version=”4.17.4″ _module_preset=”default” max_width=”84%” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/dialab.umh.es\/files\/2022\/10\/logo-ciberdem.png” alt=”Logo Ciberdem” title_text=”Logo Ciberdem” url=”https:\/\/www.ciberdem.org\/” url_new_window=”on” _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

DIALAB DIABESITY AND ISLET RESEARCH LAB \u00a0 Compromesos a comprendre els mecanismes subjacents a la c\u00e0rrega combinada de la diabetis i l’obesitatEl nostre laboratori es dedica a millorar la comprensi\u00f3 sobre la fisiopatologia de la diabetis i els trastorns metab\u00f2lics relacionats amb ella, mitjan\u00e7ant l’estudi dels factors de risc i els mecanismes cel\u00b7lulars i moleculars […]<\/p>\n","protected":false},"author":23459,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"

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D<\/strong><\/span>IALAB<\/span><\/span><\/h1>

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DIABESITY<\/span><\/h1>

AND<\/span><\/h1>

ISLET RESEARCH LAB<\/span><\/h1>

\u00a0<\/span><\/p>

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Committed to understanding the combined burden of diabetes and obesity<\/h2>

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_column type=\"4_4\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_text _builder_version=\"4.17.4\" _module_preset=\"default\" text_font=\"Roboto|300|||||||\" text_font_size=\"19px\" text_line_height=\"1.8em\" global_colors_info=\"{}\"]<\/p>

Our laboratory is dedicated to better understanding the pathophysiology of diabetes and related disorders by focusing on the study of risk factors as well as the cellular and molecular mechanisms behind. The ultimate goal is to determine new molecular targets and contribute to develop therapeutic and prevention strategies. Our studies are mainly focused on the pancreatic beta and alpha-cells, but also in other tissues involved in glucose homeostasis.<\/span><\/p>

[\/et_pb_text][et_pb_button button_text=\"READ MORE\" button_alignment=\"center\" module_class=\"rv_button\" _builder_version=\"4.17.4\" custom_button=\"on\" button_text_size=\"22px\" button_text_color=\"#ffffff\" button_bg_color=\"#333399\" button_border_color=\"#333399\" button_border_radius=\"13px\" button_icon=\";||divi||400\" background_layout=\"dark\" global_colors_info=\"{}\"][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row module_id=\"reveal\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_column type=\"4_4\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_text _builder_version=\"4.17.4\" _module_preset=\"default\" text_font=\"Roboto|700|||||||\" header_font_size=\"50px\" header_3_font_size=\"30px\" custom_margin=\"36px||||false|false\" global_colors_info=\"{}\"]<\/p>

OUR PRINCIPAL RESEARCH LINES ARE:<\/h3>

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Deciphering the mechanisms involved in the etiology of gestational diabetes mellitus (GDM) and its implication in the later development of diabetes:<\/span><\/h3>

\u00a0<\/h1>

\u00a0<\/span><\/p>

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GDM is the most common metabolic disorder of pregnancy. Its incidence is rapidly increasing all over the world and has become a public health priority issue. GDM is much more than a transient maternal hyperglycaemia occurring during pregnancy. It predisposes the mother and the offspring, both male and female, for increased risk of developing type 2 diabetes and obesity in the future. Thus, understanding the mechanisms underlying GDM will contribute to contain existing worldwide diabesity epidemic. Using in vivo and in vitro models we aim to understand the molecular basis of GDM, with particular emphasis on obesity as risk factor, and identify altered signaling pathways leading to the development of this disease. Furthermore, we aim to explore potential therapeutic tools which may present beneficial effects in the prevention and control of GDM.<\/p>

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Understanding the role of metabolism-disrupting chemicals in the occurrence of metabolic disorders:<\/span><\/h3>

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Endocrine-disrupting chemicals (EDCs) are chemical substances that can interfere with the normal function of the endocrine system. EDCs are ubiquitous and can be found in a variety of consumer products such as food packaging materials, personal care and household products, plastic additives, and flame retardants. Among them, a subset called metabolism-disrupting chemicals (MDCs) has been largely acknowledged to increase the incidence of metabolic disorders including diabetes, obesity and metabolic syndrome, among others. We study how exposure to MDCs may affect the molecular and cellular processes of the endocrine pancreas. In addition, we work to develop new and effective methods to identify EDCs with diabetogenic, obesogenic or diabesogenic effects. This will contribute to implement new testing approaches in line with the regulatory needs.<\/p>

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